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Mitoxantrone unwanted effects exist in most patients. The common ones include nausea, diarrhea, unusual fatigue, vomiting, and headache. These usually subside after a while instead of eating before a dose, eating smaller meals with greater regularity, and limiting activity may help relieve these. Dehydration may occur as a result of severe vomiting, nausea, and diarrhea. This happens infrequently, but patients experiencing an abnormal decrease in urination, not enough tears, increased thirst, dizziness or lightheadedness, great dry mouth, or wrinkled, pale skin should contact their doctor immediately. Patients can also notice their hair is thinning or thinning hair. The hair grows back next medicine is stopped. Urine may temporarily be a green blue color, but this can be harmless and healthy.